The head of the civil service Simon Case has announced he will resign at the end of the year on health grounds.
The Cabinet Secretary, 45, said in a letter to colleagues that he has been undergoing medical treatment for a neurological condition over the last 18 months.
He wrote: "Whilst the spirit remains willing, the body is not.
"It is a shame that I feel I have to spell this out, but my decision is solely to do with my health and nothing to do with anything else."
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Tap hereMr Case returned to work in January after two months off sick, though this is the first time he has publicly confirmed his condition.
He was appointed Cabinet Secretary in September 2020, making him the UK's most senior civil servant.
He has hit the headlines throughout his role, most recently regarding reports of tensions at the heart of Number 10 between Mr Case and Sir Keir Starmer's chief of staff Sue Gray.
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